The TSC Alliance is an internationally recognized nonprofit that does everything it takes to improve the lives of people with TSC. We drive research, improve quality care and access and advocate for all affected by the disease. The TSC community is our strongest ally. The collaboration of individuals and families, along with the partnership of other organizations, fuels our work to ensure people navigating TSC have support—and hope—every step of the way. Our work wouldn’t be possible without the commitment of our community. Advancing research requires dedicated investigators, individuals with TSC, government and industry. Improving quality of and access to care demands healthcare professionals and dedicated volunteers. Raising awareness takes the work of families, individuals and volunteers. We use a comprehensive approach to improve quality of life for people with TSC—fueling promising research while making sure that, day-to-day, individuals are diagnosed early and receive the highest quality care available. We also have a voice in policy around healthcare access and federal funding for TSC research. Research We ensure TSC researchers have the data and funds they need to discover breakthroughs. We fund investigators working on TSC-related studies. Often, we support focused research projects that allow researchers to develop preliminary data that will lead to additional funding from larger organizations. We also invest in early-career researchers to encourage their interest in TSC. This approach sustains their work long term and maintains momentum by fostering a diverse group of researchers dedicated to our shared mission. We ensure TSC researchers have the data and connections they need to make progress. Our Natural History Database helps us accomplish this objective. It collects clinical information from people with TSC and connects to our Biosample Repository. Researchers use this vast collection of data to answer questions and find patterns in the course of the disease over a lifespan and its variability person to person. The TSC Alliance organizes conferences and publishes a research-focused e-newsletter to facilitate connections between investigators, academic institutions and other nonprofit partners. The more they share and learn from one other, the closer our community will be to breakthroughs. The TSC Alliance fuels collaborative research through our Preclinical Consortium, bringing together industry and academia. We make preclinical testing resources available to de-risk drug development in TSC and move new treatments to clinical trials faster. We streamline the clinical trial process to bring more TSC treatments to market. By working with researchers from TSC Clinics and our community of individuals and families, we help academic and industry researchers implement trials more quickly and effectively and ensure more people with TSC have access to trials that suit their unique journeys.