The Arthur Purdy Stout Society of Surgical Pathologists (APSS) and USCAP continue their collaborative commitment to providing superb education for practicing pathologists. The Eighth Edition of Modern Surgical Pathology Through the Expert Eyes of APSS-USCAP is designed to eliminate a variety of practice gaps in diagnostic surgical pathology. The faculty’s review of the literature and collective clinical experience as consultant surgical pathologists have revealed areas that remain problematic for pathologists. Examples include the evaluation for invasion in biopsies of the genitourinary tract, the distinction of benign processes from intraepithelial neoplasia in the breast, the classification of inflammatory conditions of the gastrointestinal tract, and the differential diagnoses of problematic gynecologic and soft tissue tumors. This course attempts to help pathologists eliminate diagnostic errors by highlighting pitfalls and providing approaches to resolve them using routine microscopic examination and immunohistochemistry. The role of adjunctive molecular tests will be discussed as appropriate. The course is designed to address both molecular tests and medical knowledge and competence with the goal of improving clinical practice. Learning Objectives Eliminate diagnostic errors by recognizing typical pitfalls and utilizing provided approaches to resolving these pitfalls in surgical pathology using both routine microscopic examination of H&E-stained sections and ancillary studies. Discuss the uses and limitations of immunohistochemistry in diagnostic surgical pathology. Discuss the role of newer adjunctive molecular tests where appropriate. Address both medical knowledge and competence with the goal of improving clinical practice.