The IEEE International Symposium on Biomedical Imaging (ISBI) is a premier scientific conference dedicated to the mathematical, algorithmic, and computational aspects of biological and biomedical imaging across all scales of observation. It fosters knowledge transfer among different imaging communities and contributes to an integrative approach to biomedical imaging. ISBI is a joint initiative of the IEEE Signal Processing Society (SPS) and the IEEE Engineering in Medicine and Biology Society (EMBS).