This conference will be of particular value for clinicians and non-clinical scientists, MD and Ph.D. of all ages interested in the biology, pathophysiology, diagnosis and treatment of bone marrow failure syndromes (BMFS) and leukaemia predisposition syndromes. We will not only discuss the standard of care in acquired but also inherited BMFS occurring in adult and pediatric patients, but particularly focus on new underlying principles and evolving new treatment strategies. In good tradition of ESH, we will put special effort on low threshold exchange between young scientists and experts in the field, as well as between clinicians and basic scientists. Meet-the-experts workshop as well as poster walks will allow to highlight topics of special attention and to enable further in-depth exchange. Our dedicated faculty will secure the highest standard of both clinical, translational and basic research.