This summit promises to be forward-looking gathering, bringing together global leaders, innovative thinkers, and dedicated clinicians in the field of cartilage repair, regeneration and joint preservation. The scientific program will highlight some of the most exciting advances shaping the future of cartilage regeneration and joint health: the ARPA-H NITRO Program’s groundbreaking Living Knee Replacement, updates from ongoing gene therapy clinical trials, organoids for regenerative medicine, a global perspective on true stem cell therapy as it is being applied in clinical practice, the evolving role of exosomes and extracellular vesicles, mitochondrial transplantation as a novel therapeutic strategy, biomaterial cell therapeutics, cutting-edge developments in injectable orthobiologics, co-morbidities and joint preservation.