The 45th Annual Meeting of the European Society for Paediatric Infectious Diseases (ESPID 2027) is a leading international conference focused on advancing knowledge, research, and clinical practice in the field of paediatric infectious diseases. The meeting brings together paediatric infectious disease specialists, microbiologists, immunologists, epidemiologists, researchers, public health professionals, and healthcare providers from Europe and around the world. ESPID 2027 provides a platform for sharing the latest scientific developments in childhood infections, including advances in diagnosis, prevention, treatment strategies, antimicrobial resistance, vaccination programmes, emerging infectious diseases, and innovative approaches in paediatric healthcare. The scientific programme includes keynote lectures, plenary sessions, interactive workshops, expert discussions, oral presentations, poster sessions, and networking opportunities. The congress highlights important topics such as antimicrobial stewardship, vaccine development, viral and bacterial infections, paediatric immunology, infection prevention, global child health, and new research findings that contribute to improving outcomes for children affected by infectious diseases. It also supports collaboration between clinicians, researchers, and healthcare organizations to promote better prevention and management of infections in children worldwide.