The 40th Annual Evaluation and Treatment of Pain Conference is a comprehensive continuing medical education program focused on the diagnosis and management of acute, chronic, cancer-related, and neuropathic pain. The course brings together experts in anesthesiology, neurology, psychiatry, rehabilitation medicine, orthopedic surgery, and pain medicine to discuss the latest advances in pharmacologic, behavioral, and interventional pain therapies. Topics include opioid management, headache disorders, spinal pain, cancer pain, regenerative medicine, medical marijuana, addiction medicine, and non-pharmacologic approaches to pain management.