The 25th European Congress of Internal Medicine (ECIM 2027) is the flagship annual congress of the European Federation of Internal Medicine (EFIM). It brings together internists, subspecialists, researchers, educators, trainees, and healthcare professionals from across Europe and around the world to discuss the latest advances in internal medicine. The 2027 congress theme is "Integrating Evidence-Based and Personalised Medicine." The scientific programme will explore how evidence-based medicine, genomics, artificial intelligence, digital health, precision medicine, and data science can be integrated into everyday clinical practice while maintaining patient-centred care. The meeting will feature keynote lectures, plenary sessions, symposia, workshops, clinical case discussions, abstract presentations, poster sessions, and networking opportunities covering a broad range of internal medicine subspecialties. ECIM 2027 provides an international platform for sharing research, improving clinical practice, fostering collaboration, and advancing education in internal medicine.