The 16th SIICA National Congress will take place on June 16– 19, 2026 in Brescia, a vibrant city, rich in history and culture, and ideally located in the heart of Lombardy. A four-day congress that will feature an outstanding scientific program covering a broad spectrum of immunology topics, ranging from allergy and autoimmunity to tumor immunology and immunotherapy, with special attention to vaccines and translational immunology. We will explore cutting-edge areas such as big data, omics and artificial intelligence, as well as fundamental aspects like cell signaling, cytokines and other soluble mediators, dendritic cells, mast cells and granulocytes, monocytes and macrophages, NK cells and ILC, and T and B lymphocytes. Topics will also include host-pathogen interactions, mucosal immunology and the microbiota, immunogenetics, immunodeficiencies, metabolism, and epigenetics, along with discussions on clinical trials and other emerging fields. This comprehensive approach ensures that every participant will find sessions of interest and opportunities for fruitful exchange.